2016 Conference USA Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 5 | 633 | 837 | 280 | 1470 | 5.25 | 294.0 |
| 2 | UTSA | 5 | 972 | 839 | 337 | 1811 | 5.37 | 362.2 |
| 3 | UTEP | 4 | 873 | 715 | 286 | 1588 | 5.55 | 397.0 |
| 4 | Western Kentucky | 5 | 478 | 1525 | 391 | 2003 | 5.12 | 400.6 |
| 5 | Middle Tennessee | 5 | 1180 | 872 | 394 | 2052 | 5.21 | 410.4 |
| 6 | Old Dominion | 5 | 817 | 1252 | 378 | 2069 | 5.47 | 413.8 |
| 7 | Louisiana Tech | 5 | 889 | 1225 | 352 | 2114 | 6.01 | 422.8 |
| 8 | North Texas | 5 | 1466 | 737 | 362 | 2203 | 6.09 | 440.6 |
| 9 | Florida International | 4 | 877 | 981 | 300 | 1858 | 6.19 | 464.5 |
| 10 | Charlotte | 4 | 651 | 1295 | 282 | 1946 | 6.90 | 486.5 |
| 11 | Marshall | 4 | 717 | 1251 | 281 | 1968 | 7.00 | 492.0 |
| 12 | Florida Atlantic | 4 | 984 | 999 | 308 | 1983 | 6.44 | 495.8 |
| 13 | Rice | 4 | 1196 | 847 | 293 | 2043 | 6.97 | 510.8 |