2016 Conference USA Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 1 | 183 | 276 | 42 | 459 | 10.93 | 459.0 |
| 2 | North Texas | 1 | 255 | 216 | 72 | 471 | 6.54 | 471.0 |
| 3 | Western Kentucky | 1 | 124 | 351 | 81 | 475 | 5.86 | 475.0 |
| 4 | Rice | 1 | 373 | 161 | 61 | 534 | 8.75 | 534.0 |
| 5 | Charlotte | 2 | 482 | 688 | 136 | 1170 | 8.60 | 585.0 |
| 6 | Marshall | 2 | 525 | 697 | 150 | 1222 | 8.15 | 611.0 |