2021 Clemson Tigers Opponent First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 74 | 128 | 22 | 224 |
| at Home | 6 | 24 | 60 | 7 | 91 |
| on Road/Neutral Site | 7 | 50 | 68 | 15 | 133 |
| in Wins | 10 | 49 | 92 | 11 | 152 |
| in Losses | 3 | 25 | 36 | 11 | 72 |
| vs. Conference | 8 | 56 | 95 | 16 | 167 |
| vs. Non-Conference | 5 | 18 | 33 | 6 | 57 |
| vs. Ranked (AP) | 4 | 29 | 55 | 12 | 96 |
| vs. Unranked (AP) | 9 | 45 | 73 | 10 | 128 |
| vs. FBS (I-A) | 12 | 70 | 123 | 22 | 215 |
| vs. FCS (I-AA) | 1 | 4 | 5 | 0 | 9 |
| vs. FBS Winning | 6 | 37 | 71 | 14 | 122 |
| vs. FBS Non-Winning | 6 | 33 | 52 | 8 | 93 |
| vs. FBS Power 5 | 11 | 70 | 118 | 20 | 208 |
| vs. FBS non-Power 5 | 1 | 0 | 5 | 2 | 7 |
| in August/September | 4 | 26 | 38 | 11 | 75 |
| in October | 4 | 26 | 44 | 5 | 75 |
| in November | 4 | 18 | 37 | 5 | 60 |
| in December/January | 1 | 4 | 9 | 1 | 14 |