2021 Iowa State Cyclones Penalty Split Stats through 01/10/2022
| Split | G | Pen. | Yards | Pen./G | Yards/G |
|---|---|---|---|---|---|
| All Games | 13 | 63 | 502 | 4.8 | 38.6 |
| at Home | 6 | 25 | 196 | 4.2 | 32.7 |
| on Road/Neutral Site | 7 | 38 | 306 | 5.4 | 43.7 |
| in Wins | 7 | 32 | 257 | 4.6 | 36.7 |
| in Losses | 6 | 31 | 245 | 5.2 | 40.8 |
| vs. Conference | 9 | 40 | 324 | 4.4 | 36.0 |
| vs. Non-Conference | 4 | 23 | 178 | 5.8 | 44.5 |
| vs. Ranked (AP) | 5 | 25 | 210 | 5.0 | 42.0 |
| vs. Unranked (AP) | 8 | 38 | 292 | 4.8 | 36.5 |
| vs. FBS (I-A) | 12 | 59 | 471 | 4.9 | 39.3 |
| vs. FCS (I-AA) | 1 | 4 | 31 | 4.0 | 31.0 |
| vs. FBS Winning | 7 | 34 | 284 | 4.9 | 40.6 |
| vs. FBS Non-Winning | 5 | 25 | 187 | 5.0 | 37.4 |
| vs. FBS Power 5 | 11 | 52 | 419 | 4.7 | 38.1 |
| vs. FBS non-Power 5 | 1 | 7 | 52 | 7.0 | 52.0 |
| in August/September | 4 | 18 | 133 | 4.5 | 33.3 |
| in October | 4 | 18 | 144 | 4.5 | 36.0 |
| in November | 4 | 19 | 155 | 4.8 | 38.8 |
| in December/January | 1 | 8 | 70 | 8.0 | 70.0 |