2021 Louisville Cardinals Opponent Penalty Split Stats through 01/10/2022
| Split | G | Pen. | Yards | Pen./G | Yards/G |
|---|---|---|---|---|---|
| All Games | 13 | 72 | 587 | 5.5 | 45.2 |
| at Home | 7 | 36 | 282 | 5.1 | 40.3 |
| on Road/Neutral Site | 6 | 36 | 305 | 6.0 | 50.8 |
| in Wins | 6 | 30 | 232 | 5.0 | 38.7 |
| in Losses | 7 | 42 | 355 | 6.0 | 50.7 |
| vs. Conference | 8 | 42 | 328 | 5.3 | 41.0 |
| vs. Non-Conference | 5 | 30 | 259 | 6.0 | 51.8 |
| vs. Ranked (AP) | 5 | 32 | 264 | 6.4 | 52.8 |
| vs. Unranked (AP) | 8 | 40 | 323 | 5.0 | 40.4 |
| vs. FBS (I-A) | 12 | 70 | 572 | 5.8 | 47.7 |
| vs. FCS (I-AA) | 1 | 2 | 15 | 2.0 | 15.0 |
| vs. FBS Winning | 7 | 42 | 354 | 6.0 | 50.6 |
| vs. FBS Non-Winning | 5 | 28 | 218 | 5.6 | 43.6 |
| vs. FBS Power 5 | 10 | 60 | 482 | 6.0 | 48.2 |
| vs. FBS non-Power 5 | 2 | 10 | 90 | 5.0 | 45.0 |
| in August/September | 4 | 27 | 225 | 6.8 | 56.3 |
| in October | 4 | 23 | 181 | 5.8 | 45.3 |
| in November | 4 | 19 | 146 | 4.8 | 36.5 |
| in December/January | 1 | 3 | 35 | 3.0 | 35.0 |