2021 Oklahoma State Cowboys Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 14 | 1227 | 2943 | 910 | 4170 | 4.58 | 297.9 |
| at Home | 7 | 815 | 1327 | 449 | 2142 | 4.77 | 306.0 |
| on Road/Neutral Site | 7 | 412 | 1616 | 461 | 2028 | 4.40 | 289.7 |
| in Wins | 12 | 1098 | 2456 | 783 | 3554 | 4.54 | 296.2 |
| in Losses | 2 | 129 | 487 | 127 | 616 | 4.85 | 308.0 |
| vs. Conference | 10 | 899 | 1734 | 602 | 2633 | 4.37 | 263.3 |
| vs. Non-Conference | 4 | 328 | 1209 | 308 | 1537 | 4.99 | 384.3 |
| vs. Ranked (AP) | 4 | 400 | 1114 | 290 | 1514 | 5.22 | 378.5 |
| vs. Unranked (AP) | 10 | 827 | 1829 | 620 | 2656 | 4.28 | 265.6 |
| vs. FBS (I-A) | 13 | 1125 | 2709 | 827 | 3834 | 4.64 | 294.9 |
| vs. FCS (I-AA) | 1 | 102 | 234 | 83 | 336 | 4.05 | 336.0 |
| vs. FBS Winning | 9 | 738 | 2168 | 606 | 2906 | 4.80 | 322.9 |
| vs. FBS Non-Winning | 4 | 387 | 541 | 221 | 928 | 4.20 | 232.0 |
| vs. FBS Power 5 | 10 | 899 | 1734 | 602 | 2633 | 4.37 | 263.3 |
| vs. FBS non-Power 5 | 3 | 226 | 975 | 225 | 1201 | 5.34 | 400.3 |
| in August/September | 4 | 348 | 898 | 275 | 1246 | 4.53 | 311.5 |
| in October | 4 | 411 | 703 | 234 | 1114 | 4.76 | 278.5 |
| in November | 4 | 364 | 653 | 251 | 1017 | 4.05 | 254.3 |
| in December/January | 2 | 104 | 689 | 150 | 793 | 5.29 | 396.5 |