2016 Conference USA Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 10 | 75 | 65 | 19 | 159 | 15.9 |
| 2 | North Texas | 11 | 131 | 91 | 27 | 249 | 22.6 |
| 3 | Rice | 9 | 84 | 93 | 11 | 188 | 20.9 |
| 3 | UTEP | 10 | 121 | 93 | 16 | 230 | 23.0 |
| 5 | UTSA | 10 | 86 | 99 | 24 | 209 | 20.9 |
| 6 | Marshall | 9 | 93 | 102 | 22 | 217 | 24.1 |
| 7 | Florida Atlantic | 9 | 107 | 103 | 15 | 225 | 25.0 |
| 8 | Old Dominion | 11 | 104 | 111 | 16 | 231 | 21.0 |
| 9 | Florida International | 10 | 94 | 117 | 10 | 221 | 22.1 |
| 10 | Middle Tennessee | 10 | 114 | 129 | 14 | 257 | 25.7 |
| 11 | Western Kentucky | 11 | 61 | 134 | 27 | 222 | 20.2 |
| 12 | Charlotte | 10 | 74 | 137 | 20 | 231 | 23.1 |
| 13 | Louisiana Tech | 11 | 101 | 144 | 15 | 260 | 23.6 |