2016 Atlantic Coast Conference Leaders Opponent First Downs - Games Lost Only through 01/09/2017
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 7 | 11 | 5 | 23 | 23.0 |
| 2 | Florida State | 3 | 28 | 42 | 7 | 77 | 25.7 |
| 3 | Georgia Tech | 4 | 39 | 49 | 2 | 90 | 22.5 |
| 4 | Louisville | 4 | 28 | 52 | 11 | 91 | 22.8 |
| 5 | Miami (Florida) | 4 | 40 | 47 | 6 | 93 | 23.3 |
| 5 | Virginia Tech | 4 | 43 | 37 | 13 | 93 | 23.3 |
| 7 | North Carolina | 5 | 58 | 42 | 10 | 110 | 22.0 |
| 8 | Pittsburgh | 5 | 33 | 84 | 8 | 125 | 25.0 |
| 9 | Boston College | 6 | 48 | 63 | 16 | 127 | 21.2 |
| 9 | Wake Forest | 6 | 68 | 55 | 4 | 127 | 21.2 |
| 11 | North Carolina State | 6 | 48 | 81 | 13 | 142 | 23.7 |
| 12 | Duke | 8 | 80 | 69 | 8 | 157 | 19.6 |
| 13 | Syracuse | 8 | 92 | 102 | 10 | 204 | 25.5 |
| 14 | Virginia | 10 | 92 | 101 | 18 | 211 | 21.1 |