2018 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 3 | 6.0 | 35 | 2.00 |
| 2 | North Texas | 1 | 5.0 | 27 | 5.00 |
| 3 | Middle Tennessee | 3 | 4.0 | 34 | 1.33 |
| 3 | Marshall | 2 | 4.0 | 32 | 2.00 |
| 3 | Louisiana Tech | 2 | 4.0 | 31 | 2.00 |
| 3 | Western Kentucky | 2 | 4.0 | 24 | 2.00 |
| 3 | Old Dominion | 1 | 4.0 | 23 | 4.00 |
| 8 | Southern Mississippi | 1 | 3.0 | 26 | 3.00 |
| 8 | Florida International | 2 | 3.0 | 24 | 1.50 |
| 10 | Charlotte | 1 | 2.0 | 20 | 2.00 |
| 10 | UTEP | 1 | 2.0 | 14 | 2.00 |
| 10 | Florida Atlantic | 1 | 2.0 | 13 | 2.00 |
| 10 | Rice | 2 | 2.0 | 8 | 1.00 |
| 14 | UAB | 1 | 1.0 | 4 | 1.00 |