2020 Conference USA Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 1 | 188 | 325 | 64 | 513 | 8.02 | 513.0 |
| 2 | Florida International | 1 | 219 | 308 | 79 | 527 | 6.67 | 527.0 |
| 3 | Southern Mississippi | 1 | 192 | 345 | 69 | 537 | 7.78 | 537.0 |
| 4 | UTEP | 1 | 208 | 481 | 74 | 689 | 9.31 | 689.0 |
| 5 | UAB | 2 | 471 | 310 | 141 | 781 | 5.54 | 390.5 |
| 6 | UTSA | 2 | 443 | 438 | 137 | 881 | 6.43 | 440.5 |
| 7 | Western Kentucky | 2 | 520 | 377 | 148 | 897 | 6.06 | 448.5 |