2020 Big 12 Conference Leaders Long Rushing Plays - Games vs. FBS Power 5 Conference Teams Only through 01/11/2021
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | SO | RB | 11 | 35 | 14 | 8 | 4 | 4 | 3 | 2 | 0 | 0 |
| 1 | Bijan Robinson | Texas | FR | RB | 8 | 17 | 9 | 5 | 4 | 4 | 2 | 1 | 0 | 0 |
| 3 | LD Brown | Okla St | SR | RB | 8 | 11 | 3 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | Max Duggan | TCU | SO | QB | 9 | 18 | 8 | 5 | 4 | 2 | 1 | 1 | 1 | 0 |
| 3 | Will Howard | Kansas St | FR | QB | 8 | 9 | 5 | 2 | 2 | 2 | 2 | 1 | 1 | 0 |
| 3 | SaRodorick Thompson | Texas Tech | SO | RB | 9 | 11 | 5 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 7 | Darwin Barlow | TCU | FR | RB | 9 | 10 | 5 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Leddie Brown | WVU | JR | RB | 8 | 24 | 5 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Malik Knowles | Kansas St | SO | WR | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Seth McGowan | Oklahoma | FR | RB | 7 | 10 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Myles Price | Texas Tech | FR | WR | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Dominic Richardson | Okla St | FR | RB | 7 | 4 | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 7 | Rhamondre Stevenson | Oklahoma | SR | RB | 6 | 22 | 7 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 7 | Xavier White | Texas Tech | SO | RB | 8 | 12 | 5 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |