2021 Conference USA Leaders Rushing - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | DeWayne McBride | UAB | SO | RB | 2 | 41 | 244 | 5.95 | 1 | 20.50 | 122.00 |
| 2 | Rasheen Ali | Marshall | FR | RB | 1 | 20 | 160 | 8.00 | 3 | 20.00 | 160.00 |
| 3 | Khalan Griffin | Rice | FR | RB | 2 | 32 | 121 | 3.78 | 0 | 16.00 | 60.50 |
| 4 | Brenden Brady | UTSA | SR | RB | 1 | 16 | 76 | 4.75 | 1 | 16.00 | 76.00 |
| 4 | Jermaine Brown Jr. | UAB | JR | RB | 2 | 14 | 76 | 5.43 | 0 | 7.00 | 38.00 |
| 6 | Austin Kendall | La Tech | SR | QB | 1 | 15 | 71 | 4.73 | 0 | 15.00 | 71.00 |
| 7 | Elijah Davis | ODU | SO | RB | 1 | 12 | 69 | 5.75 | 0 | 12.00 | 69.00 |
| 8 | Marcus Williams Jr. | La Tech | SR | RB | 1 | 16 | 59 | 3.69 | 0 | 16.00 | 59.00 |
| 9 | Ari Broussard | Rice | SO | RB | 2 | 14 | 56 | 4.00 | 0 | 7.00 | 28.00 |
| 10 | Blake Watson | ODU | SO | RB | 1 | 15 | 55 | 3.67 | 0 | 15.00 | 55.00 |
| 11 | Ty Keyes | USM | FR | QB | 1 | 12 | 41 | 3.42 | 0 | 12.00 | 41.00 |
| 12 | B.J. Daniels | UTSA | SR | RB | 1 | 3 | 38 | 12.67 | 0 | 3.00 | 38.00 |
| 13 | Noah Whittington | Western Ky | FR | RB | 1 | 7 | 37 | 5.29 | 0 | 7.00 | 37.00 |
| 14 | Chandler Pittman | USM | FR | RB | 1 | 6 | 28 | 4.67 | 0 | 6.00 | 28.00 |
| 15 | Jordan Myers | Rice | SR | TE | 2 | 10 | 23 | 2.30 | 1 | 5.00 | 11.50 |
| 16 | Willie Johnson | Marshall | SR | WR | 1 | 2 | 21 | 10.50 | 0 | 2.00 | 21.00 |
| 16 | Lucious Stanley | UAB | SR | RB | 2 | 4 | 21 | 5.25 | 0 | 2.00 | 10.50 |
| 18 | Larry Wooden | UAB | SR | RB | 2 | 2 | 19 | 9.50 | 0 | 1.00 | 9.50 |
| 19 | Kye Robichaux | Western Ky | FR | RB | 1 | 6 | 18 | 3.00 | 0 | 6.00 | 18.00 |
| 20 | Adam Cofield | Western Ky | SR | RB | 1 | 3 | 15 | 5.00 | 0 | 3.00 | 15.00 |
| 21 | D.J. Mack Jr. | ODU | JR | QB | 1 | 8 | 13 | 1.63 | 0 | 8.00 | 13.00 |
| 22 | Sheldon Evans | Marshall | JR | RB | 1 | 4 | 12 | 3.00 | 0 | 4.00 | 12.00 |
| 23 | Luke McCaffrey | Rice | FR | QB | 2 | 12 | 11 | 0.92 | 0 | 6.00 | 5.50 |
| 24 | C.J. Jones | Western Ky | JR | RB | 1 | 2 | 10 | 5.00 | 0 | 2.00 | 10.00 |
| 25 | Jakairi Moses | Western Ky | SO | RB | 1 | 1 | 9 | 9.00 | 0 | 1.00 | 9.00 |
| 26 | Keyon Henry-Brooks | La Tech | SO | RB | 1 | 2 | 8 | 4.00 | 0 | 2.00 | 8.00 |
| 27 | Dajon Richard | USM | FR | RB | 1 | 4 | 7 | 1.75 | 0 | 4.00 | 7.00 |
| 27 | Frank Gore, Jr. | USM | FR | RB | 1 | 9 | 7 | 0.78 | 0 | 9.00 | 7.00 |
| 27 | Brendan Suckley | Rice | SO | FB | 2 | 2 | 7 | 3.50 | 0 | 1.00 | 3.50 |
| 30 | Keshawn Wicks | ODU | FR | RB | 1 | 1 | 4 | 4.00 | 0 | 1.00 | 4.00 |
| 31 | Jon-Luke Peaker | ODU | FR | RB | 1 | 1 | 3 | 3.00 | 0 | 1.00 | 3.00 |
| 32 | De'Corian Clark | UTSA | JR | WR | 1 | 1 | 2 | 2.00 | 0 | 1.00 | 2.00 |
| 32 | Tyler Johnston III | UAB | SR | QB | 1 | 3 | 2 | 0.67 | 0 | 3.00 | 2.00 |
| 34 | Kevin Dominique | La Tech | JR | RB | 1 | 1 | 1 | 1.00 | 0 | 1.00 | 1.00 |
| 34 | Tee Webb | USM | FR | QB | 1 | 1 | 1 | 1.00 | 0 | 1.00 | 1.00 |
| 34 | Stone Smartt | ODU | SR | QB | 1 | 2 | 1 | 0.50 | 0 | 2.00 | 1.00 |
| 34 | Frank Harris | UTSA | SR | QB | 1 | 4 | 1 | 0.25 | 0 | 4.00 | 1.00 |