2021 Conference USA Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rasheen Ali | Marshall | FR | RB | 1 | 160 | 0 | 20 | 160 | 8.00 | 160.0 |
| 2 | Austin Kendall | La Tech | SR | QB | 1 | 71 | 341 | 58 | 412 | 7.10 | 412.0 |
| 3 | Bailey Zappe | Western Ky | SR | QB | 1 | -17 | 488 | 71 | 471 | 6.63 | 471.0 |
| 4 | Frank Harris | UTSA | SR | QB | 1 | 1 | 255 | 40 | 256 | 6.40 | 256.0 |
| 5 | DeWayne McBride | UAB | SO | RB | 2 | 244 | 0 | 41 | 244 | 5.95 | 122.0 |
| 6 | Elijah Davis | ODU | SO | RB | 1 | 69 | 0 | 12 | 69 | 5.75 | 69.0 |
| 7 | Hayden Wolff | ODU | FR | QB | 1 | 0 | 88 | 17 | 88 | 5.18 | 88.0 |
| 8 | Dylan Hopkins | UAB | JR | QB | 2 | -10 | 197 | 38 | 187 | 4.92 | 93.5 |
| 9 | Ty Keyes | USM | FR | QB | 1 | 41 | 131 | 36 | 172 | 4.78 | 172.0 |
| 10 | Brenden Brady | UTSA | SR | RB | 1 | 76 | 0 | 16 | 76 | 4.75 | 76.0 |
| 11 | Luke McCaffrey | Rice | FR | QB | 2 | 11 | 161 | 41 | 172 | 4.20 | 86.0 |
| 12 | Khalan Griffin | Rice | FR | RB | 2 | 121 | 0 | 32 | 121 | 3.78 | 60.5 |
| 13 | Marcus Williams Jr. | La Tech | SR | RB | 1 | 59 | 0 | 16 | 59 | 3.69 | 59.0 |
| 14 | Blake Watson | ODU | SO | RB | 1 | 55 | 0 | 15 | 55 | 3.67 | 55.0 |
| 15 | Grant Wells | Marshall | FR | QB | 1 | -6 | 99 | 30 | 93 | 3.10 | 93.0 |
| 16 | D.J. Mack Jr. | ODU | JR | QB | 1 | 13 | 39 | 29 | 52 | 1.79 | 52.0 |
| 17 | Frank Gore, Jr. | USM | FR | RB | 1 | 7 | 0 | 9 | 7 | 0.78 | 7.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.