2021 Conference USA Leaders All Purpose - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Stone Smartt | ODU | SR | QB | 1 | 1 | 26 | 0 | 52 | 7 | 79 | 11.3 | 79.0 |
| 2 | Sean Fresch | Rice | FR | CB | 2 | 0 | 0 | 16 | 39 | 4 | 55 | 13.8 | 27.5 |
| 3 | Camron Harrell | USM | JR | DB | 1 | 0 | 0 | 0 | 37 | 2 | 37 | 18.5 | 37.0 |
| 4 | Shadeed Ahmed | Marshall | SO | WR | 1 | 0 | 27 | 0 | 22 | 3 | 49 | 16.3 | 49.0 |
| 4 | Antavious Willis | USM | FR | DB | 1 | 0 | 0 | 0 | 22 | 1 | 22 | 22.0 | 22.0 |
| 6 | Bub Means | La Tech | FR | WR | 1 | 0 | 95 | 0 | 21 | 7 | 116 | 16.6 | 116.0 |
| 7 | Jayden Harrison | Marshall | SO | WR | 1 | 0 | 6 | 0 | 20 | 2 | 26 | 13.0 | 26.0 |
| 8 | Jordan Myers | Rice | SR | TE | 2 | 23 | 52 | 0 | 16 | 18 | 91 | 5.1 | 45.5 |
| 9 | Jermaine Brown Jr. | UAB | JR | RB | 2 | 76 | 19 | 0 | 15 | 19 | 110 | 5.8 | 55.0 |
| 10 | LaMareon James | ODU | FR | CB | 1 | 0 | 0 | 0 | 12 | 1 | 12 | 12.0 | 12.0 |