2021 Conference USA Leaders Passing - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 13 | 622 | 429 | 69.0 | 5479 | 8.8 | 59 | 11 | 170.73 | 47.8 | 421.5 |
| 2 | Grant Wells | Marshall | FR | QB | 12 | 418 | 280 | 67.0 | 3436 | 8.2 | 16 | 12 | 142.93 | 34.8 | 286.3 |
| 3 | Frank Harris | UTSA | SR | QB | 13 | 363 | 241 | 66.4 | 2906 | 8.0 | 25 | 5 | 153.62 | 27.9 | 223.5 |
| 4 | Dylan Hopkins | UAB | JR | QB | 11 | 209 | 134 | 64.1 | 2078 | 9.9 | 15 | 6 | 165.58 | 19.0 | 188.9 |
| 5 | Chris Reynolds | Charlotte | SR | QB | 11 | 337 | 215 | 63.8 | 2684 | 8.0 | 26 | 9 | 150.82 | 30.6 | 244.0 |
| 6 | Hayden Wolff | ODU | FR | QB | 9 | 236 | 148 | 62.7 | 1845 | 7.8 | 9 | 7 | 135.04 | 26.2 | 205.0 |
| 7 | Jake Constantine | Rice | SR | QB | 8 | 206 | 126 | 61.2 | 1622 | 7.9 | 8 | 7 | 133.32 | 25.8 | 202.8 |
| 8 | N'Kosi Perry | FAU | SR | QB | 12 | 345 | 210 | 60.9 | 2762 | 8.0 | 20 | 7 | 143.19 | 28.8 | 230.2 |
| 9 | Gavin Hardison | UTEP | SO | QB | 13 | 359 | 198 | 55.2 | 3223 | 9.0 | 18 | 13 | 139.88 | 27.6 | 247.9 |
| 10 | Max Bortenschlager | FIU | SR | QB | 12 | 342 | 178 | 52.0 | 2935 | 8.6 | 19 | 12 | 135.45 | 28.5 | 244.6 |
| 11 | Austin Aune | N Texas | SO | QB | 13 | 295 | 151 | 51.2 | 1992 | 6.8 | 9 | 9 | 111.89 | 22.7 | 153.2 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.