2021 Conference USA Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 2 | 0 | 999 | 115 | 999 | 8.69 | 499.5 |
| 2 | Nicholas Vattiato | MTSU | FR | QB | 1 | 9 | 270 | 41 | 279 | 6.80 | 279.0 |
| 3 | Frank Harris | UTSA | SR | QB | 2 | 82 | 473 | 79 | 555 | 7.03 | 277.5 |
| 4 | Gavin Hardison | UTEP | SO | QB | 1 | 8 | 252 | 32 | 260 | 8.13 | 260.0 |
| 5 | Austin Aune | N Texas | SO | QB | 1 | 28 | 228 | 41 | 256 | 6.24 | 256.0 |
| 6 | Dylan Hopkins | UAB | JR | QB | 1 | -5 | 189 | 28 | 184 | 6.57 | 184.0 |
| 7 | DeWayne McBride | UAB | SO | RB | 1 | 183 | 0 | 28 | 183 | 6.54 | 183.0 |
| 8 | Hayden Wolff | ODU | FR | QB | 1 | -7 | 176 | 29 | 169 | 5.83 | 169.0 |
| 9 | Rasheen Ali | Marshall | FR | RB | 1 | 160 | 0 | 20 | 160 | 8.00 | 160.0 |
| 10 | Sincere McCormick | UTSA | JR | RB | 2 | 204 | 0 | 36 | 204 | 5.67 | 102.0 |
| 11 | Grant Wells | Marshall | FR | QB | 1 | -6 | 99 | 30 | 93 | 3.10 | 93.0 |
| 12 | Noah Whittington | Western Ky | FR | RB | 2 | 165 | 0 | 11 | 165 | 15.00 | 82.5 |
| 13 | Blake Watson | ODU | SO | RB | 1 | 77 | 0 | 14 | 77 | 5.50 | 77.0 |
| 14 | Frank Peasant | MTSU | FR | RB | 1 | 64 | 0 | 15 | 64 | 4.27 | 64.0 |
| 15 | Brenden Brady | UTSA | SR | RB | 2 | 97 | 24 | 23 | 121 | 5.26 | 60.5 |
| 16 | Calvin Brownholtz | UTEP | SO | QB | 1 | 2 | 51 | 3 | 53 | 17.67 | 53.0 |
| 17 | Mike DiLiello | MTSU | SO | QB | 1 | 44 | 6 | 10 | 50 | 5.00 | 50.0 |
| 18 | Jermaine Brown Jr. | UAB | JR | RB | 1 | 47 | 0 | 8 | 47 | 5.88 | 47.0 |
| 19 | Ronald Awatt | UTEP | JR | RB | 1 | 40 | 0 | 14 | 40 | 2.86 | 40.0 |
| 20 | Kye Robichaux | Western Ky | FR | RB | 2 | 71 | 0 | 13 | 71 | 5.46 | 35.5 |
| 21 | Deion Hankins | UTEP | FR | RB | 1 | 33 | 0 | 6 | 33 | 5.50 | 33.0 |
| 22 | Jaylin Lane | MTSU | FR | WR | 1 | 26 | 0 | 5 | 26 | 5.20 | 26.0 |
| 23 | Ikaika Ragsdale | N Texas | FR | RB | 1 | 23 | 0 | 11 | 23 | 2.09 | 23.0 |
| 24 | Willie Johnson | Marshall | SR | WR | 1 | 21 | 0 | 2 | 21 | 10.50 | 21.0 |
| 24 | Isaiah Johnson | N Texas | FR | RB | 1 | 21 | 0 | 6 | 21 | 3.50 | 21.0 |
| 26 | B.J. Daniels | UTSA | SR | RB | 2 | 38 | 0 | 3 | 38 | 12.67 | 19.0 |
| 27 | Ayo Adeyi | N Texas | FR | RB | 1 | 17 | 0 | 6 | 17 | 2.83 | 17.0 |
| 28 | Martell Pettaway | MTSU | SR | RB | 1 | 13 | 0 | 7 | 13 | 1.86 | 13.0 |
| 29 | Justin Garrett | UTEP | SR | WR | 1 | 12 | 0 | 1 | 12 | 12.00 | 12.0 |
| 29 | Sheldon Evans | Marshall | JR | RB | 1 | 12 | 0 | 4 | 12 | 3.00 | 12.0 |
| 31 | Brad Anderson | MTSU | SR | RB | 1 | 8 | 0 | 2 | 8 | 4.00 | 8.0 |
| 32 | Joshua Cephus | UTSA | JR | WR | 2 | 0 | 10 | 2 | 10 | 5.00 | 5.0 |
| 33 | Jakairi Moses | Western Ky | SO | RB | 2 | 9 | 0 | 4 | 9 | 2.25 | 4.5 |
| 34 | Jacob Cowing | UTEP | SO | WR | 1 | 3 | 0 | 1 | 3 | 3.00 | 3.0 |
| 35 | Stone Smartt | ODU | SR | QB | 1 | 2 | 0 | 1 | 2 | 2.00 | 2.0 |
| 36 | De'Corian Clark | UTSA | JR | WR | 2 | 2 | 0 | 1 | 2 | 2.00 | 1.0 |
| 36 | Jerreth Sterns | Western Ky | JR | WR | 2 | 2 | 0 | 1 | 2 | 2.00 | 1.0 |
| 36 | Elijah Davis | ODU | SO | RB | 1 | 1 | 0 | 2 | 1 | 0.50 | 1.0 |
| 36 | Amir Rasul | MTSU | SR | RB | 1 | 1 | 0 | 3 | 1 | 0.33 | 1.0 |
| 40 | Adam Cofield | Western Ky | SR | RB | 2 | 1 | 0 | 1 | 1 | 1.00 | 0.5 |
| 41 | Reynaldo Flores | UTEP | JR | RB | 1 | 0 | 0 | 1 | 0 | 0.00 | 0.0 |
Note: To qualify, player must have played in 75% of his team's games.