2021 Conference USA Leaders Sacks - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clarence Hicks | UTSA | SR | OLB | 2 | 2.5 | 16 | 1.25 |
| 1 | Brodric Martin | Western Ky | JR | DT | 2 | 2.5 | 16 | 1.25 |
| 3 | TJ Johnson | Marshall | SR | DL | 1 | 1.5 | 9 | 1.50 |
| 3 | DeAngelo Malone | Western Ky | SR | DE | 2 | 1.5 | 2 | 0.75 |
| 5 | Marcus Bragg | Western Ky | JR | DE | 2 | 1.0 | 15 | 0.50 |
| 5 | Gabriel Murphy | N Texas | FR | DE | 1 | 1.0 | 8 | 1.00 |
| 5 | Jordan Young | ODU | SR | LB | 1 | 1.0 | 7 | 1.00 |
| 5 | Dion Novil | N Texas | SR | DL | 1 | 1.0 | 6 | 1.00 |
| 5 | Fish McWilliams | UAB | JR | DL | 1 | 1.0 | 5 | 1.00 |
| 5 | Charles Wiley | UTSA | SR | OLB | 2 | 1.0 | 5 | 0.50 |
| 5 | Jordan Ferguson | MTSU | JR | DE | 1 | 1.0 | 4 | 1.00 |
| 5 | Grayson Murphy | N Texas | FR | DE | 1 | 1.0 | 2 | 1.00 |
| 5 | Torey Richardson | UTEP | SO | CB | 1 | 1.0 | 1 | 1.00 |
| 14 | Kevin Wood | N Texas | SO | LB | 1 | 0.5 | 5 | 0.50 |
| 14 | KD Davis | N Texas | JR | LB | 1 | 0.5 | 5 | 0.50 |
| 14 | Owen Porter | Marshall | SO | DL | 1 | 0.5 | 3 | 0.50 |
| 14 | Jamal Ligon | UTSA | SO | ILB | 2 | 0.5 | 3 | 0.25 |