2021 Conference USA Leaders Scoring Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 4 | 21 | 2 | 19 | 1 | 0 | 153 | 38.3 |
| 2 | Middle Tennessee | 5 | 21 | 6 | 20 | 1 | 1 | 168 | 33.6 |
| 3 | UTEP | 4 | 20 | 10 | 19 | 0 | 1 | 171 | 42.8 |
| 4 | Southern Mississippi | 5 | 24 | 5 | 24 | 0 | 1 | 185 | 37.0 |
| 5 | UTSA | 6 | 25 | 7 | 19 | 1 | 0 | 192 | 32.0 |
| 6 | UAB | 6 | 26 | 4 | 23 | 1 | 0 | 193 | 32.2 |
| 7 | Florida Atlantic | 6 | 25 | 6 | 24 | 1 | 0 | 194 | 32.3 |
| 8 | Florida International | 5 | 26 | 8 | 25 | 0 | 1 | 207 | 41.4 |
| 9 | Marshall | 6 | 28 | 8 | 25 | 0 | 0 | 217 | 36.2 |
| 10 | Louisiana Tech | 6 | 29 | 7 | 27 | 0 | 1 | 224 | 37.3 |
| 11 | Old Dominion | 7 | 27 | 12 | 25 | 1 | 0 | 225 | 32.1 |
| 12 | North Texas | 7 | 29 | 8 | 28 | 0 | 0 | 226 | 32.3 |
| 13 | Rice | 6 | 31 | 5 | 30 | 0 | 0 | 231 | 38.5 |
| 14 | Western Kentucky | 7 | 36 | 5 | 36 | 0 | 0 | 267 | 38.1 |