2021 Conference USA Leaders Total Defense - Games Won Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida International | 1 | 96 | 195 | 67 | 291 | 4.34 | 291.0 |
| 2 | Southern Mississippi | 3 | 372 | 421 | 179 | 793 | 4.43 | 264.3 |
| 3 | Louisiana Tech | 3 | 444 | 1035 | 242 | 1479 | 6.11 | 493.0 |
| 4 | Florida Atlantic | 5 | 419 | 1251 | 339 | 1670 | 4.93 | 334.0 |
| 5 | Rice | 4 | 402 | 1300 | 268 | 1702 | 6.35 | 425.5 |
| 6 | North Texas | 6 | 791 | 1212 | 390 | 2003 | 5.14 | 333.8 |
| 7 | UTEP | 7 | 687 | 1321 | 448 | 2008 | 4.48 | 286.9 |
| 8 | Old Dominion | 6 | 694 | 1464 | 411 | 2158 | 5.25 | 359.7 |
| 9 | Charlotte | 5 | 927 | 1376 | 335 | 2303 | 6.87 | 460.6 |
| 10 | Middle Tennessee | 7 | 764 | 1556 | 513 | 2320 | 4.52 | 331.4 |
| 11 | Marshall | 7 | 1373 | 1021 | 519 | 2394 | 4.61 | 342.0 |
| 12 | UAB | 9 | 879 | 1590 | 591 | 2469 | 4.18 | 274.3 |
| 13 | Western Kentucky | 9 | 1197 | 2352 | 685 | 3549 | 5.18 | 394.3 |
| 14 | UTSA | 12 | 1110 | 3163 | 771 | 4273 | 5.54 | 356.1 |