2021 Conference USA Leaders Total Defense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 2 | 496 | 449 | 153 | 945 | 6.18 | 472.5 |
| 2 | UAB | 4 | 570 | 1235 | 260 | 1805 | 6.94 | 451.3 |
| 3 | Middle Tennessee | 6 | 1004 | 1519 | 428 | 2523 | 5.89 | 420.5 |
| 4 | Old Dominion | 7 | 1050 | 1797 | 528 | 2847 | 5.39 | 406.7 |
| 5 | UTEP | 6 | 1118 | 1409 | 421 | 2527 | 6.00 | 421.2 |
| 6 | Marshall | 6 | 1123 | 1639 | 484 | 2762 | 5.71 | 460.3 |
| 7 | Western Kentucky | 5 | 1161 | 1401 | 398 | 2562 | 6.44 | 512.4 |
| 8 | North Texas | 7 | 1185 | 1778 | 485 | 2963 | 6.11 | 423.3 |
| 9 | Florida Atlantic | 7 | 1467 | 1719 | 503 | 3186 | 6.33 | 455.1 |
| 10 | Southern Mississippi | 9 | 1496 | 2004 | 564 | 3500 | 6.21 | 388.9 |
| 11 | Charlotte | 7 | 1519 | 1754 | 447 | 3273 | 7.32 | 467.6 |
| 12 | Rice | 8 | 1542 | 1987 | 514 | 3529 | 6.87 | 441.1 |
| 13 | Louisiana Tech | 9 | 1554 | 2179 | 613 | 3733 | 6.09 | 414.8 |
| 14 | Florida International | 11 | 2662 | 2959 | 815 | 5621 | 6.90 | 511.0 |