2021 Conference USA Leaders Scoring Defense - Games in October Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 4 | 9 | 1 | 8 | 0 | 0 | 65 | 16.3 |
| 2 | Marshall | 4 | 9 | 2 | 8 | 0 | 0 | 68 | 17.0 |
| 2 | UAB | 4 | 11 | 2 | 8 | 0 | 0 | 80 | 20.0 |
| 4 | Florida Atlantic | 4 | 11 | 3 | 9 | 1 | 0 | 86 | 21.5 |
| 4 | North Texas | 4 | 21 | 3 | 21 | 0 | 0 | 156 | 39.0 |
| 6 | UTSA | 4 | 10 | 4 | 7 | 0 | 0 | 79 | 19.8 |
| 6 | Middle Tennessee | 4 | 11 | 4 | 10 | 1 | 1 | 92 | 23.0 |
| 6 | Rice | 4 | 15 | 4 | 14 | 0 | 1 | 118 | 29.5 |
| 6 | Southern Mississippi | 4 | 15 | 4 | 15 | 0 | 1 | 119 | 29.8 |
| 10 | Charlotte | 4 | 18 | 5 | 17 | 0 | 0 | 140 | 35.0 |
| 10 | Florida International | 4 | 23 | 5 | 22 | 0 | 0 | 175 | 43.8 |
| 12 | Louisiana Tech | 4 | 14 | 7 | 14 | 0 | 1 | 121 | 30.3 |
| 12 | Western Kentucky | 5 | 19 | 7 | 17 | 0 | 0 | 152 | 30.4 |
| 14 | Old Dominion | 4 | 12 | 9 | 10 | 1 | 0 | 111 | 27.8 |