2021 Conference USA Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 4 | 332 | 768 | 250 | 1100 | 4.40 | 275.0 |
| 2 | Marshall | 4 | 802 | 525 | 287 | 1327 | 4.62 | 331.8 |
| 3 | Middle Tennessee | 4 | 516 | 964 | 301 | 1480 | 4.92 | 370.0 |
| 4 | UAB | 4 | 468 | 809 | 255 | 1277 | 5.01 | 319.3 |
| 5 | Florida Atlantic | 4 | 384 | 1098 | 277 | 1482 | 5.35 | 370.5 |
| 6 | Old Dominion | 4 | 413 | 1163 | 290 | 1576 | 5.43 | 394.0 |
| 7 | UTSA | 4 | 310 | 1214 | 279 | 1524 | 5.46 | 381.0 |
| 8 | Louisiana Tech | 4 | 644 | 876 | 275 | 1520 | 5.53 | 380.0 |
| 9 | North Texas | 4 | 602 | 1067 | 290 | 1669 | 5.76 | 417.3 |
| 10 | Western Kentucky | 5 | 721 | 1417 | 365 | 2138 | 5.86 | 427.6 |
| 11 | Southern Mississippi | 4 | 741 | 642 | 231 | 1383 | 5.99 | 345.8 |
| 12 | Rice | 4 | 638 | 904 | 248 | 1542 | 6.22 | 385.5 |
| 13 | Florida International | 4 | 869 | 1199 | 297 | 2068 | 6.96 | 517.0 |
| 14 | Charlotte | 4 | 686 | 1162 | 246 | 1848 | 7.51 | 462.0 |