2021 Conference USA Leaders Opponent Penalties - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 13 | 106 | 861 | 8.2 | 66.2 |
| 2 | Old Dominion | 12 | 93 | 843 | 7.8 | 70.3 |
| 3 | Charlotte | 11 | 85 | 743 | 7.7 | 67.5 |
| 4 | Florida Atlantic | 11 | 83 | 734 | 7.5 | 66.7 |
| 5 | North Texas | 12 | 89 | 781 | 7.4 | 65.1 |
| 6 | Louisiana Tech | 11 | 79 | 775 | 7.2 | 70.5 |
| 7 | Southern Mississippi | 11 | 77 | 697 | 7.0 | 63.4 |
| 7 | Western Kentucky | 13 | 91 | 780 | 7.0 | 60.0 |
| 9 | UTEP | 12 | 81 | 778 | 6.8 | 64.8 |
| 10 | Rice | 11 | 73 | 725 | 6.6 | 65.9 |
| 10 | Middle Tennessee | 12 | 79 | 651 | 6.6 | 54.3 |
| 12 | Marshall | 12 | 72 | 668 | 6.0 | 55.7 |
| 13 | UAB | 12 | 67 | 585 | 5.6 | 48.8 |
| 14 | Florida International | 11 | 57 | 543 | 5.2 | 49.4 |