2021 Conference USA Leaders Rushing Offense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 7 | 123 | 575 | 4.67 | 13 | 41 | 36 | 20 | 4 |
| 2 | North Texas | 4 | 99 | 521 | 5.26 | 6 | 42 | 31 | 18 | 3 |
| 3 | UTSA | 6 | 132 | 616 | 4.67 | 5 | 47 | 30 | 18 | 8 |
| 3 | Florida Atlantic | 5 | 68 | 403 | 5.93 | 5 | 60 | 20 | 16 | 4 |
| 5 | Western Kentucky | 9 | 128 | 517 | 4.04 | 4 | 28 | 26 | 16 | 5 |
| 5 | UAB | 5 | 108 | 402 | 3.72 | 4 | 37 | 17 | 12 | 3 |
| 7 | Middle Tennessee | 5 | 71 | 284 | 4.00 | 3 | 57 | 15 | 10 | 4 |
| 7 | Old Dominion | 3 | 56 | 252 | 4.50 | 3 | 28 | 14 | 7 | 2 |
| 9 | Southern Mississippi | 3 | 28 | 229 | 8.18 | 1 | 56 | 9 | 6 | 5 |
| 9 | Florida International | 2 | 25 | 173 | 6.92 | 1 | 28 | 7 | 7 | 1 |
| 9 | Charlotte | 2 | 26 | 101 | 3.88 | 1 | 15 | 6 | 4 | 0 |
| 12 | UTEP | 3 | 46 | 192 | 4.17 | 0 | 44 | 6 | 6 | 1 |
| 12 | Rice | 1 | 6 | 17 | 2.83 | 0 | 9 | 0 | 0 | 0 |
| 12 | Louisiana Tech | 2 | 16 | -11 | -0.69 | 0 | 7 | 1 | 0 | 0 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||