2021 Conference USA Leaders Total Offense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 6 | 596 | 2548 | 431 | 3144 | 7.29 | 524.0 |
| 2 | Marshall | 6 | 951 | 1836 | 470 | 2787 | 5.93 | 464.5 |
| 3 | UTSA | 7 | 1145 | 1820 | 493 | 2965 | 6.01 | 423.6 |
| 4 | Florida International | 6 | 724 | 1778 | 375 | 2502 | 6.67 | 417.0 |
| 5 | Florida Atlantic | 6 | 1203 | 1707 | 463 | 2910 | 6.29 | 485.0 |
| 6 | Charlotte | 6 | 927 | 1642 | 416 | 2569 | 6.18 | 428.2 |
| 7 | Louisiana Tech | 6 | 802 | 1571 | 408 | 2373 | 5.82 | 395.5 |
| 8 | UTEP | 6 | 843 | 1563 | 404 | 2406 | 5.96 | 401.0 |
| 9 | Old Dominion | 6 | 1132 | 1528 | 453 | 2660 | 5.87 | 443.3 |
| 10 | Rice | 6 | 987 | 1461 | 420 | 2448 | 5.83 | 408.0 |
| 11 | North Texas | 6 | 1508 | 983 | 486 | 2491 | 5.13 | 415.2 |
| 12 | Middle Tennessee | 5 | 812 | 962 | 343 | 1774 | 5.17 | 354.8 |
| 13 | UAB | 5 | 948 | 934 | 292 | 1882 | 6.45 | 376.4 |
| 14 | Southern Mississippi | 6 | 814 | 815 | 358 | 1629 | 4.55 | 271.5 |