2021 Conference USA Leaders Interceptions - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | UTSA | 7 | 7 | 190 | 3 | 1.00 |
| 2 | Middle Tennessee | 7 | 8 | 158 | 2 | 1.14 |
| 3 | UAB | 6 | 7 | 152 | 1 | 1.17 |
| 4 | Marshall | 6 | 8 | 128 | 0 | 1.33 |
| 5 | Old Dominion | 5 | 3 | 88 | 1 | 0.60 |
| 6 | North Texas | 5 | 1 | 75 | 0 | 0.20 |
| 7 | Southern Mississippi | 6 | 5 | 67 | 2 | 0.83 |
| 8 | Louisiana Tech | 5 | 4 | 57 | 0 | 0.80 |
| 9 | Western Kentucky | 6 | 10 | 45 | 0 | 1.67 |
| 10 | Charlotte | 7 | 5 | 44 | 2 | 0.71 |
| 11 | UTEP | 8 | 6 | 23 | 0 | 0.75 |
| 12 | Florida Atlantic | 5 | 6 | 21 | 0 | 1.20 |
| 13 | Rice | 5 | 8 | 14 | 0 | 1.60 |
| 14 | Florida International | 6 | 2 | 0 | 0 | 0.33 |