2021 Conference USA Leaders Tackles For Loss - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 7 | 53.0 | 230 | 7.57 |
| 2 | Middle Tennessee | 7 | 51.0 | 212 | 7.29 |
| 2 | UAB | 6 | 45.0 | 212 | 7.50 |
| 4 | Western Kentucky | 6 | 43.0 | 210 | 7.17 |
| 5 | UTEP | 8 | 52.0 | 207 | 6.50 |
| 6 | North Texas | 5 | 40.0 | 162 | 8.00 |
| 6 | Southern Mississippi | 6 | 35.0 | 162 | 5.83 |
| 8 | Marshall | 6 | 37.0 | 153 | 6.17 |
| 9 | Charlotte | 7 | 35.0 | 148 | 5.00 |
| 10 | Rice | 5 | 29.0 | 131 | 5.80 |
| 11 | Louisiana Tech | 5 | 36.0 | 111 | 7.20 |
| 12 | Florida Atlantic | 5 | 29.0 | 109 | 5.80 |
| 12 | Old Dominion | 5 | 24.0 | 109 | 4.80 |
| 14 | Florida International | 6 | 28.0 | 81 | 4.67 |