2021 Conference USA Leaders Sacks - Games in August/September Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Marshall | 4 | 18.0 | 100 | 4.50 |
| 2 | Southern Mississippi | 4 | 11.0 | 82 | 2.75 |
| 3 | UTSA | 4 | 7.0 | 64 | 1.75 |
| 4 | Old Dominion | 4 | 8.0 | 61 | 2.00 |
| 5 | North Texas | 4 | 9.0 | 60 | 2.25 |
| 6 | UTEP | 4 | 8.0 | 59 | 2.00 |
| 7 | Rice | 4 | 7.0 | 55 | 1.75 |
| 8 | Louisiana Tech | 4 | 8.0 | 50 | 2.00 |
| 8 | Charlotte | 4 | 8.0 | 50 | 2.00 |
| 10 | Middle Tennessee | 4 | 6.0 | 44 | 1.50 |
| 11 | Western Kentucky | 3 | 5.0 | 37 | 1.67 |
| 12 | Florida International | 4 | 7.0 | 36 | 1.75 |
| 13 | UAB | 4 | 3.0 | 27 | 0.75 |
| 14 | Florida Atlantic | 4 | 3.0 | 26 | 0.75 |