2021 Conference USA Leaders Total Offense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 5 | 564 | 2183 | 406 | 2747 | 6.77 | 549.4 |
| 2 | North Texas | 4 | 900 | 773 | 313 | 1673 | 5.35 | 418.3 |
| 3 | Marshall | 4 | 663 | 1153 | 309 | 1816 | 5.88 | 454.0 |
| 4 | Old Dominion | 4 | 577 | 776 | 292 | 1353 | 4.63 | 338.3 |
| 5 | Middle Tennessee | 4 | 544 | 796 | 273 | 1340 | 4.91 | 335.0 |
| 6 | UTEP | 4 | 614 | 933 | 272 | 1547 | 5.69 | 386.8 |
| 6 | Louisiana Tech | 4 | 352 | 1142 | 272 | 1494 | 5.49 | 373.5 |
| 8 | UTSA | 4 | 770 | 985 | 270 | 1755 | 6.50 | 438.8 |
| 9 | Florida Atlantic | 4 | 673 | 1023 | 263 | 1696 | 6.45 | 424.0 |
| 9 | Florida International | 4 | 277 | 1227 | 263 | 1504 | 5.72 | 376.0 |
| 9 | Southern Mississippi | 4 | 197 | 776 | 263 | 973 | 3.70 | 243.3 |
| 12 | Rice | 4 | 412 | 719 | 259 | 1131 | 4.37 | 282.8 |
| 13 | Charlotte | 4 | 527 | 793 | 258 | 1320 | 5.12 | 330.0 |
| 14 | UAB | 4 | 656 | 809 | 236 | 1465 | 6.21 | 366.3 |