2021 Conference USA Leaders Turnover Margin - Games in October Only through 01/10/2022
| Name | G | Fum. Gain | Int. Gain | Total Gain | Fum. Lost | Int. Lost | Total Lost | Margin | Margin/G | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 4 | 7 | 10 | 17 | 5 | 3 | 8 | 9 | 2.25 |
| 2 | UTSA | 4 | 3 | 7 | 10 | 1 | 1 | 2 | 8 | 2.00 |
| 3 | UAB | 4 | 4 | 4 | 8 | 3 | 2 | 5 | 3 | 0.75 |
| 4 | Florida Atlantic | 4 | 2 | 5 | 7 | 2 | 3 | 5 | 2 | 0.50 |
| 4 | Rice | 4 | 1 | 5 | 6 | 2 | 2 | 4 | 2 | 0.50 |
| 6 | Western Kentucky | 5 | 3 | 4 | 7 | 3 | 4 | 7 | 0 | 0.00 |
| 6 | UTEP | 4 | 2 | 5 | 7 | 3 | 4 | 7 | 0 | 0.00 |
| 8 | Marshall | 4 | 2 | 6 | 8 | 5 | 5 | 10 | -2 | -0.50 |
| 8 | Louisiana Tech | 4 | 4 | 2 | 6 | 1 | 7 | 8 | -2 | -0.50 |
| 8 | Charlotte | 4 | 2 | 3 | 5 | 3 | 4 | 7 | -2 | -0.50 |
| 11 | Florida International | 4 | 1 | 0 | 1 | 1 | 3 | 4 | -3 | -0.75 |
| 12 | North Texas | 4 | 1 | 1 | 2 | 1 | 6 | 7 | -5 | -1.25 |
| 13 | Southern Mississippi | 4 | 4 | 2 | 6 | 3 | 9 | 12 | -6 | -1.50 |
| 13 | Old Dominion | 4 | 0 | 3 | 3 | 3 | 6 | 9 | -6 | -1.50 |