2021 Conference USA Leaders Total Offense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 4 | 421 | 1612 | 305 | 2033 | 6.67 | 508.3 |
| 2 | North Texas | 4 | 1222 | 805 | 320 | 2027 | 6.33 | 506.8 |
| 3 | Old Dominion | 4 | 669 | 1141 | 267 | 1810 | 6.78 | 452.5 |
| 4 | Rice | 4 | 682 | 1109 | 302 | 1791 | 5.93 | 447.8 |
| 5 | Charlotte | 4 | 489 | 1262 | 280 | 1751 | 6.25 | 437.8 |
| 6 | UTSA | 4 | 671 | 997 | 264 | 1668 | 6.32 | 417.0 |
| 7 | Marshall | 4 | 580 | 1049 | 274 | 1629 | 5.95 | 407.3 |
| 8 | UAB | 4 | 823 | 794 | 244 | 1617 | 6.63 | 404.3 |
| 9 | UTEP | 4 | 457 | 1090 | 255 | 1547 | 6.07 | 386.8 |
| 10 | Louisiana Tech | 4 | 604 | 923 | 285 | 1527 | 5.36 | 381.8 |
| 11 | Middle Tennessee | 4 | 612 | 867 | 308 | 1479 | 4.80 | 369.8 |
| 12 | Florida Atlantic | 4 | 473 | 980 | 281 | 1453 | 5.17 | 363.3 |
| 13 | Florida International | 4 | 392 | 834 | 238 | 1226 | 5.15 | 306.5 |
| 14 | Southern Mississippi | 4 | 756 | 400 | 219 | 1156 | 5.28 | 289.0 |