2021 Conference USA Leaders First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 14 | 36 | 3 | 53 | 26.5 |
| 2 | Middle Tennessee | 1 | 10 | 13 | 3 | 26 | 26.0 |
| 3 | UTSA | 2 | 20 | 22 | 7 | 49 | 24.5 |
| 4 | UAB | 1 | 12 | 11 | 0 | 23 | 23.0 |
| 5 | North Texas | 1 | 5 | 13 | 0 | 18 | 18.0 |
| 6 | UTEP | 1 | 3 | 10 | 3 | 16 | 16.0 |
| 7 | Marshall | 1 | 8 | 5 | 0 | 13 | 13.0 |
| 8 | Old Dominion | 1 | 4 | 6 | 0 | 10 | 10.0 |