2021 Big 12 Conference Leaders Long Scrimmage Plays - All Games through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Breece Hall | Iowa State | JR | RB | 12 | 48 | 20 | 13 | 7 | 4 | 3 | 3 | 1 | 0 |
| 1 | Xavier Worthy | Texas | FR | WR | 12 | 31 | 15 | 10 | 5 | 4 | 3 | 1 | 0 | 0 |
| 3 | Taye Barber | TCU | SR | WR | 12 | 19 | 9 | 4 | 3 | 3 | 2 | 1 | 0 | 0 |
| 3 | Daniel Imatorbhebhe | Kansas St | SR | TE | 12 | 10 | 6 | 3 | 2 | 2 | 2 | 1 | 0 | 0 |
| 3 | Kendre Miller | TCU | SO | RB | 10 | 16 | 9 | 6 | 5 | 4 | 2 | 1 | 0 | 0 |
| 3 | Deuce Vaughn | Kansas St | SO | RB | 13 | 59 | 18 | 10 | 7 | 4 | 2 | 1 | 1 | 0 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 11 | 13 | 8 | 6 | 6 | 4 | 2 | 1 | 0 | 0 |
| 8 | Kennedy Brooks | Oklahoma | JR | RB | 13 | 36 | 17 | 8 | 3 | 1 | 1 | 0 | 0 | 0 |
| 8 | Tahj Brooks | Texas Tech | SO | RB | 9 | 16 | 5 | 4 | 4 | 2 | 1 | 0 | 0 | 0 |
| 8 | Leddie Brown | WVU | SR | RB | 12 | 34 | 11 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 8 | Derius Davis | TCU | SR | WR | 12 | 24 | 9 | 6 | 5 | 1 | 1 | 0 | 0 | 0 |
| 8 | Trestan Ebner | Baylor | SR | RB | 14 | 36 | 11 | 7 | 3 | 2 | 1 | 0 | 0 | 0 |
| 8 | Erik Ezukanma | Texas Tech | JR | WR | 11 | 32 | 12 | 9 | 5 | 3 | 1 | 1 | 0 | 0 |
| 8 | Loic Fouonji | Texas Tech | SO | WR | 10 | 4 | 2 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 8 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 13 | 21 | 9 | 6 | 4 | 3 | 1 | 1 | 0 | 0 |
| 8 | Garrett Greene | WVU | FR | QB | 11 | 14 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Will Howard | Kansas St | SO | QB | 6 | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Roschon Johnson | Texas | JR | RB | 12 | 14 | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Quentin Johnston | TCU | SO | WR | 9 | 25 | 12 | 6 | 4 | 2 | 1 | 1 | 0 | 0 |
| 8 | Malik Knowles | Kansas St | JR | WR | 13 | 21 | 7 | 5 | 4 | 2 | 1 | 0 | 0 | 0 |
| 8 | Travis Koontz | Texas Tech | SR | TE | 12 | 9 | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 8 | Kwamie Lassiter II | Kansas | SR | WR | 12 | 25 | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Tarique Milton | Iowa State | SR | WR | 12 | 9 | 5 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 8 | Marvin Mims | Oklahoma | SO | WR | 13 | 26 | 12 | 8 | 8 | 4 | 1 | 0 | 0 | 0 |
| 8 | Devin Neal | Kansas | FR | RB | 11 | 17 | 4 | 3 | 3 | 2 | 1 | 0 | 0 | 0 |
| 8 | Jaden Nixon | Okla St | FR | RB | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Bijan Robinson | Texas | SO | RB | 10 | 38 | 12 | 6 | 2 | 2 | 1 | 0 | 0 | 0 |
| 8 | Keilan Robinson | Texas | JR | RB | 11 | 10 | 6 | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
| 8 | Abram Smith | Baylor | SR | RB | 14 | 46 | 17 | 11 | 4 | 2 | 1 | 1 | 0 | 0 |
| 8 | R.J. Sneed | Baylor | SR | WR | 14 | 20 | 10 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | SaRodorick Thompson | Texas Tech | JR | RB | 11 | 19 | 7 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Tyquan Thornton | Baylor | SR | WR | 14 | 41 | 13 | 7 | 7 | 1 | 1 | 1 | 0 | 0 |
| 8 | Jaylen Warren | Okla St | SR | RB | 14 | 41 | 13 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 8 | Trevon West | Oklahoma | SO | WR | 13 | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |