2021 Big 12 Conference Leaders Long Kickoff Return Plays - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Malik Knowles | Kansas St | JR | WR | 6 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 2 | Jaylin Noel | Iowa State | FR | WR | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | D'Shawn Jamison | Texas | SR | DB | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Derius Davis | TCU | SR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 4 | Trestan Ebner | Baylor | SR | RB | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Kenny Logan Jr. | Kansas | JR | S | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Marvin Mims | Oklahoma | SO | WR | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Brennan Presley | Okla St | SO | WR | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Dominic Richardson | Okla St | SO | RB | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Eli Sanders | Iowa State | FR | RB | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | JD Spielman | TCU | SR | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Chadarius Townsend | Texas Tech | SR | RB | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Mario Williams | Oklahoma | FR | WR | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |