2021 Big 12 Conference Leaders All Purpose - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Quentin Johnston | TCU | SO | WR | 3 | 8 | 346 | 0 | 0 | 15 | 354 | 23.6 | 118.0 |
| 2 | Malik Knowles | Kansas St | JR | WR | 3 | 12 | 95 | 0 | 258 | 18 | 365 | 20.3 | 121.7 |
| 3 | Erik Ezukanma | Texas Tech | JR | WR | 4 | 32 | 322 | 0 | 0 | 22 | 354 | 16.1 | 88.5 |
| 4 | Brennan Presley | Okla St | SO | WR | 4 | 9 | 207 | -2 | 168 | 24 | 382 | 15.9 | 95.5 |
| 5 | Derius Davis | TCU | SR | WR | 3 | 8 | 94 | 29 | 195 | 21 | 326 | 15.5 | 108.7 |
| 6 | Winston Wright Jr. | WVU | JR | WR | 3 | 1 | 171 | 0 | 146 | 24 | 318 | 13.3 | 106.0 |
| 7 | Tay Martin | Okla St | SR | WR | 4 | 4 | 391 | 0 | 0 | 33 | 395 | 12.0 | 98.8 |
| 8 | Charlie Kolar | Iowa State | SR | TE | 5 | 0 | 359 | 0 | 0 | 31 | 359 | 11.6 | 71.8 |
| 9 | Xavier Hutchinson | Iowa State | SR | WR | 5 | 10 | 271 | 0 | 0 | 28 | 281 | 10.0 | 56.2 |
| 10 | Eric Gray | Oklahoma | JR | RB | 3 | 86 | 40 | 0 | 72 | 21 | 198 | 9.4 | 66.0 |
| 11 | Jaylin Noel | Iowa State | FR | WR | 5 | 0 | 117 | 51 | 78 | 27 | 246 | 9.1 | 49.2 |
| 11 | Sam James | WVU | JR | WR | 3 | 9 | 137 | 0 | 0 | 16 | 146 | 9.1 | 48.7 |
| 13 | Phillip Brooks | Kansas St | JR | WR | 3 | 0 | 128 | -4 | 0 | 15 | 124 | 8.3 | 41.3 |
| 14 | Kennedy Brooks | Oklahoma | JR | RB | 3 | 336 | 49 | 0 | 0 | 54 | 385 | 7.1 | 128.3 |
| 15 | Deuce Vaughn | Kansas St | SO | RB | 3 | 201 | 214 | 0 | 0 | 59 | 415 | 7.0 | 138.3 |
| 16 | Trestan Ebner | Baylor | SR | RB | 5 | 189 | 62 | 29 | 190 | 68 | 470 | 6.9 | 94.0 |
| 17 | Abram Smith | Baylor | SR | RB | 5 | 668 | 20 | 0 | 0 | 102 | 688 | 6.7 | 137.6 |
| 18 | Emari Demercado | TCU | SR | RB | 3 | 206 | 63 | 0 | 0 | 45 | 269 | 6.0 | 89.7 |
| 19 | Tahj Brooks | Texas Tech | SO | RB | 4 | 198 | 24 | 0 | 21 | 42 | 243 | 5.8 | 60.8 |
| 20 | Bijan Robinson | Texas | SO | RB | 5 | 487 | 121 | 0 | 0 | 107 | 608 | 5.7 | 121.6 |
| 21 | Spencer Sanders | Okla St | JR | QB | 4 | 323 | 6 | 0 | 0 | 59 | 329 | 5.6 | 82.3 |
| 21 | Gerry Bohanon | Baylor | JR | QB | 4 | 150 | 0 | 0 | 0 | 27 | 150 | 5.6 | 37.5 |
| 23 | Breece Hall | Iowa State | JR | RB | 4 | 387 | 129 | 0 | 0 | 97 | 516 | 5.3 | 129.0 |
| 24 | Jason Bean | Kansas | JR | QB | 3 | 145 | 0 | 0 | 0 | 35 | 145 | 4.1 | 48.3 |
| 25 | Jaylen Warren | Okla St | SR | RB | 4 | 263 | 66 | 0 | 0 | 83 | 329 | 4.0 | 82.3 |
| 26 | Xavier White | Texas Tech | JR | RB | 4 | 66 | 26 | 0 | 0 | 25 | 92 | 3.7 | 23.0 |
| 27 | Devin Neal | Kansas | FR | RB | 3 | 158 | -2 | 0 | 0 | 43 | 156 | 3.6 | 52.0 |
| 27 | Jirehl Brock | Iowa State | SO | RB | 5 | 78 | 23 | 0 | 0 | 28 | 101 | 3.6 | 20.2 |
| 29 | Garrett Greene | WVU | FR | QB | 3 | 73 | 0 | 0 | 0 | 21 | 73 | 3.5 | 24.3 |
| 30 | Leddie Brown | WVU | SR | RB | 3 | 124 | 14 | 0 | 0 | 43 | 138 | 3.2 | 46.0 |
| 31 | Dominic Richardson | Okla St | SO | RB | 4 | 30 | 8 | 0 | 15 | 21 | 53 | 2.5 | 13.3 |
| 32 | Caleb Williams | Oklahoma | FR | QB | 3 | 87 | 0 | 0 | 0 | 36 | 87 | 2.4 | 29.0 |
| 33 | Casey Thompson | Texas | JR | QB | 5 | 47 | 0 | 0 | 0 | 26 | 47 | 1.8 | 9.4 |
| 34 | Donovan Smith | Texas Tech | FR | QB | 3 | 3 | 0 | 0 | 0 | 22 | 3 | 0.1 | 1.0 |
| 35 | Brock Purdy | Iowa State | SR | QB | 5 | -27 | 0 | 0 | 0 | 38 | -27 | -0.7 | -5.4 |
| 36 | Jarret Doege | WVU | SR | QB | 3 | -50 | 0 | 0 | 0 | 25 | -50 | -2.0 | -16.7 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.