2021 Big 12 Conference Leaders Tackles - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Solo | Assisted | Total | Total/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Dillon Doyle | Baylor | JR | LB | 5 | 20 | 22 | 42 | 8.40 |
| 2 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 24 | 21 | 45 | 11.25 |
| 3 | DeMarvion Overshown | Texas | SR | LB | 5 | 18 | 20 | 38 | 7.60 |
| 4 | Eric Monroe | Texas Tech | SR | DB | 4 | 15 | 19 | 34 | 8.50 |
| 5 | Luke Brockermeyer | Texas | JR | LB | 5 | 22 | 18 | 40 | 8.00 |
| 5 | Zach Petersen | Iowa State | SR | DE | 5 | 5 | 18 | 23 | 4.60 |
| 7 | Devin Harper | Okla St | SR | LB | 4 | 16 | 16 | 32 | 8.00 |
| 8 | Terrel Bernard | Baylor | SR | LB | 4 | 26 | 15 | 41 | 10.25 |
| 8 | Colin Schooler | Texas Tech | SR | LB | 4 | 25 | 15 | 40 | 10.00 |
| 10 | Mike Rose | Iowa State | SR | LB | 4 | 10 | 14 | 24 | 6.00 |
| 10 | Ovie Oghoufo | Texas | JR | EDG | 5 | 10 | 14 | 24 | 4.80 |
| 10 | Gerry Vaughn | Iowa State | JR | LB | 5 | 5 | 14 | 19 | 3.80 |
| 13 | Josh Chandler-Semedo | WVU | SR | LB | 3 | 14 | 13 | 27 | 9.00 |
| 13 | Jake Hummel | Iowa State | SR | LB | 5 | 13 | 13 | 26 | 5.20 |
| 13 | B.J. Foster | Texas | SR | DB | 5 | 13 | 13 | 26 | 5.20 |
| 16 | Cody Fletcher | Kansas St | SR | LB | 3 | 11 | 12 | 23 | 7.67 |
| 16 | Jamoi Hodge | TCU | SO | LB | 3 | 10 | 12 | 22 | 7.33 |
| 16 | Eyioma Uwazurike | Iowa State | SR | DE | 5 | 6 | 12 | 18 | 3.60 |
| 19 | Matt Jones | Baylor | SO | LB | 5 | 16 | 11 | 27 | 5.40 |
| 19 | Greg Eisworth II | Iowa State | SR | DB | 5 | 14 | 11 | 25 | 5.00 |
| 19 | Jaylan Ford | Texas | SO | LB | 5 | 12 | 11 | 23 | 4.60 |
| 22 | Riko Jeffers | Texas Tech | SR | LB | 4 | 11 | 10 | 21 | 5.25 |
| 23 | Jalen Pitre | Baylor | SR | S | 5 | 22 | 9 | 31 | 6.20 |
| 23 | T.J. Carter | TCU | SR | S | 3 | 14 | 9 | 23 | 7.67 |
| 23 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 3 | 14 | 9 | 23 | 7.67 |
| 23 | Krishon Merriweather | Texas Tech | SR | LB | 4 | 8 | 9 | 17 | 4.25 |
| 23 | O'Rien Vance | Iowa State | SR | LB | 3 | 5 | 9 | 14 | 4.67 |
| 23 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 5 | 9 | 14 | 3.50 |
| 29 | Anthony Johnson Jr. | Iowa State | SR | DB | 5 | 15 | 8 | 23 | 4.60 |
| 29 | Beau Freyler | Iowa State | FR | DB | 5 | 14 | 8 | 22 | 4.40 |
| 29 | Sean Mahone | WVU | SR | S | 3 | 13 | 8 | 21 | 7.00 |
| 29 | Alonzo Addae | WVU | SR | S | 3 | 12 | 8 | 20 | 6.67 |
| 29 | Patrick Fields | Oklahoma | SR | S | 3 | 10 | 8 | 18 | 6.00 |
| 29 | Dylan Horton | TCU | SR | DE | 3 | 9 | 8 | 17 | 5.67 |
| 29 | Isheem Young | Iowa State | SO | DB | 4 | 9 | 8 | 17 | 4.25 |
| 29 | Felix Anudike-Uzomah | Kansas St | SO | DE | 3 | 8 | 8 | 16 | 5.33 |
| 29 | Brenden Schooler | Texas | SR | DB | 5 | 6 | 8 | 14 | 2.80 |
| 38 | Kenny Logan Jr. | Kansas | JR | S | 3 | 22 | 7 | 29 | 9.67 |
| 38 | Brian Asamoah | Oklahoma | JR | LB | 2 | 18 | 7 | 25 | 12.50 |
| 38 | Reggie Pearson Jr. | Texas Tech | JR | DB | 3 | 16 | 7 | 23 | 7.67 |
| 38 | JT Woods | Baylor | SR | S | 5 | 16 | 7 | 23 | 4.60 |
| 38 | Josh Thompson | Texas | SR | DB | 5 | 16 | 7 | 23 | 4.60 |
| 38 | Craig McDonald | Iowa State | FR | DB | 5 | 14 | 7 | 21 | 4.20 |
| 38 | Ray Thornton | Texas | SR | EDG | 5 | 14 | 7 | 21 | 4.20 |
| 38 | Dee Winters | TCU | JR | LB | 3 | 10 | 7 | 17 | 5.67 |
| 38 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 10 | 7 | 17 | 4.25 |
| 38 | David Ugwoegbu | Oklahoma | JR | LB | 3 | 8 | 7 | 15 | 5.00 |
| 38 | David Gbenda | Texas | SO | LB | 5 | 7 | 7 | 14 | 2.80 |
| 38 | TJ Franklin | Baylor | JR | DL | 5 | 6 | 7 | 13 | 2.60 |
| 38 | Moro Ojomo | Texas | JR | DL | 5 | 5 | 7 | 12 | 2.40 |