2021 Big 12 Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Collin Oliver | Okla St | FR | DE | 4 | 6.0 | 46 | 1.50 |
| 2 | Terrel Bernard | Baylor | SR | LB | 4 | 5.5 | 35 | 1.38 |
| 3 | Will McDonald IV | Iowa State | JR | DE | 5 | 5.0 | 32 | 1.00 |
| 4 | Eyioma Uwazurike | Iowa State | SR | DE | 5 | 3.5 | 20 | 0.70 |
| 5 | Bryson Jackson | Baylor | SR | OLB | 5 | 3.0 | 24 | 0.60 |
| 5 | Brock Martin | Okla St | SR | DE | 3 | 3.0 | 16 | 1.00 |
| 7 | TJ Franklin | Baylor | JR | DL | 5 | 2.5 | 16 | 0.50 |
| 8 | Jalen Pitre | Baylor | SR | S | 5 | 2.0 | 17 | 0.40 |
| 8 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 2.0 | 16 | 0.50 |
| 8 | Tyree Wilson | Texas Tech | JR | DL | 4 | 2.0 | 16 | 0.50 |
| 8 | Ochaun Mathis | TCU | JR | DE | 3 | 2.0 | 15 | 0.67 |
| 8 | Tony Bradford Jr. | Texas Tech | JR | DL | 3 | 2.0 | 10 | 0.67 |
| 8 | Timmy Horne | Kansas St | SR | DT | 3 | 2.0 | 9 | 0.67 |
| 8 | Taijh Alston | WVU | JR | DL | 3 | 2.0 | 7 | 0.67 |
| 8 | Felix Anudike-Uzomah | Kansas St | SO | DE | 3 | 2.0 | 6 | 0.67 |
| 8 | Mike Rose | Iowa State | SR | LB | 4 | 2.0 | 6 | 0.50 |
| 17 | Jason Taylor II | Okla St | JR | S | 4 | 1.5 | 15 | 0.38 |
| 17 | DeMarvion Overshown | Texas | SR | LB | 5 | 1.5 | 13 | 0.30 |
| 17 | Brendon Evers | Okla St | SR | DT | 4 | 1.5 | 7 | 0.38 |
| 17 | Cole Maxwell | Baylor | SR | DT | 5 | 1.5 | 7 | 0.30 |
| 21 | Nate Matlack | Kansas St | FR | DE | 3 | 1.0 | 12 | 0.33 |
| 21 | Caleb Sampson | Kansas | SR | DL | 3 | 1.0 | 11 | 0.33 |
| 21 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 1.0 | 11 | 0.25 |
| 21 | Matt Jones | Baylor | SO | LB | 5 | 1.0 | 11 | 0.20 |
| 21 | Dillon Doyle | Baylor | JR | LB | 5 | 1.0 | 11 | 0.20 |
| 21 | Jake Hummel | Iowa State | SR | LB | 5 | 1.0 | 11 | 0.20 |
| 21 | Kyron Johnson | Kansas | SR | DE | 3 | 1.0 | 10 | 0.33 |
| 21 | Akheem Mesidor | WVU | SO | DL | 3 | 1.0 | 10 | 0.33 |
| 21 | Nook Bradford | TCU | JR | S | 3 | 1.0 | 9 | 0.33 |
| 21 | Jett Bush | Texas | JR | LB | 4 | 1.0 | 9 | 0.25 |
| 21 | Tre Sterling | Okla St | SR | S | 2 | 1.0 | 8 | 0.50 |
| 21 | Daniel Green | Kansas St | JR | LB | 3 | 1.0 | 8 | 0.33 |
| 21 | Brayden Utley | Baylor | JR | DL | 5 | 1.0 | 8 | 0.20 |
| 21 | Garmon Randolph | Baylor | SO | OLB | 5 | 1.0 | 7 | 0.20 |
| 21 | Siaki Ika | Baylor | SO | DT | 5 | 1.0 | 7 | 0.20 |
| 21 | Keondre Coburn | Texas | JR | DL | 5 | 1.0 | 7 | 0.20 |
| 21 | Alfred Collins | Texas | SO | DL | 5 | 1.0 | 7 | 0.20 |
| 21 | Gabe Hall | Baylor | SO | DL | 4 | 1.0 | 6 | 0.25 |
| 21 | Ray Thornton | Texas | SR | EDG | 5 | 1.0 | 6 | 0.20 |
| 21 | Ovie Oghoufo | Texas | JR | EDG | 5 | 1.0 | 6 | 0.20 |
| 21 | Marcus Stripling | Oklahoma | JR | DE | 3 | 1.0 | 5 | 0.33 |
| 21 | Jalen Redmond | Oklahoma | SO | DL | 3 | 1.0 | 5 | 0.33 |
| 21 | Devin Harper | Okla St | SR | LB | 4 | 1.0 | 5 | 0.25 |
| 21 | Nik Bonitto | Oklahoma | JR | OLB | 2 | 1.0 | 4 | 0.50 |
| 21 | Dante Stills | WVU | SR | DL | 3 | 1.0 | 4 | 0.33 |
| 21 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1.0 | 3 | 0.25 |
| 21 | Gavin Potter | Kansas | JR | LB | 3 | 1.0 | 2 | 0.33 |
| 21 | Exree Loe | WVU | JR | LB | 3 | 1.0 | 2 | 0.33 |
| 21 | Qualan Jones | Baylor | SO | RB | 2 | 1.0 | 1 | 0.50 |
| 21 | Anthony Johnson Jr. | Iowa State | SR | DB | 5 | 1.0 | 1 | 0.20 |