2021 Big 12 Conference Leaders Passing - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Shane Illingworth | Okla St | SO | QB | 3 | 50 | 28 | 56.0 | 385 | 7.7 | 3 | 1 | 136.48 | 16.7 | 128.3 |
| 2 | Brock Purdy | Iowa State | SR | QB | 8 | 234 | 177 | 75.6 | 1995 | 8.5 | 14 | 2 | 165.29 | 29.3 | 249.4 |
| 2 | Caleb Williams | Oklahoma | FR | QB | 8 | 127 | 86 | 67.7 | 1276 | 10.0 | 15 | 2 | 187.94 | 15.9 | 159.5 |
| 4 | Tyler Shough | Texas Tech | JR | QB | 3 | 68 | 47 | 69.1 | 641 | 9.4 | 5 | 3 | 163.74 | 22.7 | 213.7 |
| 4 | Spencer Sanders | Okla St | JR | QB | 9 | 242 | 146 | 60.3 | 1807 | 7.5 | 14 | 3 | 139.66 | 26.9 | 200.8 |
| 4 | Jalon Daniels | Kansas | SO | QB | 5 | 116 | 81 | 69.8 | 860 | 7.4 | 7 | 3 | 146.85 | 23.2 | 172.0 |
| 7 | Skylar Thompson | Kansas St | SR | QB | 8 | 163 | 118 | 72.4 | 1635 | 10.0 | 9 | 4 | 169.96 | 20.4 | 204.4 |
| 7 | Gerry Bohanon | Baylor | JR | QB | 8 | 182 | 123 | 67.6 | 1633 | 9.0 | 15 | 4 | 165.75 | 22.8 | 204.1 |
| 7 | Henry Colombi | Texas Tech | SR | QB | 6 | 137 | 89 | 65.0 | 1214 | 8.9 | 4 | 4 | 143.19 | 22.8 | 202.3 |
| 7 | Jason Bean | Kansas | JR | QB | 8 | 132 | 74 | 56.1 | 939 | 7.1 | 4 | 4 | 119.76 | 16.5 | 117.4 |
| 11 | Spencer Rattler | Oklahoma | SO | QB | 8 | 181 | 136 | 75.1 | 1447 | 8.0 | 11 | 5 | 156.82 | 22.6 | 180.9 |
| 12 | Max Duggan | TCU | JR | QB | 9 | 197 | 125 | 63.5 | 1702 | 8.6 | 12 | 6 | 150.04 | 21.9 | 189.1 |
| 12 | Casey Thompson | Texas | JR | QB | 7 | 149 | 98 | 65.8 | 1168 | 7.8 | 15 | 6 | 156.79 | 21.3 | 166.9 |
| 14 | Jarret Doege | WVU | SR | QB | 10 | 335 | 217 | 64.8 | 2542 | 7.6 | 18 | 9 | 140.88 | 33.5 | 254.2 |
Note: To qualify, player must have and have a minimum of 15.0 pass attempts per game played.