2021 Big 12 Conference Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Sanders | Okla St | JR | QB | 2 | 154 | 628 | 127 | 782 | 6.16 | 391.0 |
| 2 | Donovan Smith | Texas Tech | FR | QB | 1 | 30 | 252 | 33 | 282 | 8.55 | 282.0 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 1 | 34 | 242 | 34 | 276 | 8.12 | 276.0 |
| 4 | Skylar Thompson | Kansas St | SR | QB | 1 | 10 | 259 | 33 | 269 | 8.15 | 269.0 |
| 5 | Brock Purdy | Iowa State | SR | QB | 1 | 14 | 204 | 44 | 218 | 4.95 | 218.0 |
| 6 | Deuce Vaughn | Kansas St | SO | RB | 1 | 146 | 0 | 21 | 146 | 6.95 | 146.0 |
| 7 | Kennedy Brooks | Oklahoma | JR | RB | 1 | 142 | 0 | 14 | 142 | 10.14 | 142.0 |
| 8 | Jarret Doege | WVU | SR | QB | 1 | -22 | 140 | 39 | 118 | 3.03 | 118.0 |
| 9 | Abram Smith | Baylor | SR | RB | 2 | 235 | 0 | 42 | 235 | 5.60 | 117.5 |
| 10 | Tahj Brooks | Texas Tech | SO | RB | 1 | 107 | 0 | 16 | 107 | 6.69 | 107.0 |
| 11 | Eric Gray | Oklahoma | JR | RB | 1 | 82 | 0 | 8 | 82 | 10.25 | 82.0 |
| 12 | SaRodorick Thompson | Texas Tech | JR | RB | 1 | 80 | 0 | 14 | 80 | 5.71 | 80.0 |
| 13 | Tony Mathis Jr. | WVU | SO | RB | 1 | 56 | 0 | 13 | 56 | 4.31 | 56.0 |
| 14 | Marcus Major | Oklahoma | SO | RB | 1 | 54 | 0 | 10 | 54 | 5.40 | 54.0 |
| 15 | Jirehl Brock | Iowa State | SO | RB | 1 | 42 | 0 | 14 | 42 | 3.00 | 42.0 |
| 16 | Jaylen Warren | Okla St | SR | RB | 2 | 82 | 0 | 19 | 82 | 4.32 | 41.0 |
| 17 | Justin Johnson Jr. | WVU | FR | RB | 1 | 35 | 0 | 5 | 35 | 7.00 | 35.0 |
| 18 | Trestan Ebner | Baylor | SR | RB | 2 | 53 | 0 | 11 | 53 | 4.82 | 26.5 |
| 19 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 1 | 18 | 0 | 3 | 18 | 6.00 | 18.0 |
| 19 | Jax Dineen | Kansas St | JR | FB | 1 | 18 | 0 | 4 | 18 | 4.50 | 18.0 |
| 21 | Myles Price | Texas Tech | SO | WR | 1 | 15 | 0 | 2 | 15 | 7.50 | 15.0 |
| 22 | Mario Williams | Oklahoma | FR | WR | 1 | 11 | 0 | 1 | 11 | 11.00 | 11.0 |
| 23 | Deon Silas | Iowa State | FR | RB | 1 | 10 | 0 | 2 | 10 | 5.00 | 10.0 |
| 23 | Xavier White | Texas Tech | JR | RB | 1 | 10 | 0 | 4 | 10 | 2.50 | 10.0 |
| 25 | Brennan Presley | Okla St | SO | WR | 2 | 9 | 6 | 3 | 15 | 5.00 | 7.5 |
| 26 | Jordan Schippers | Kansas St | SO | RB | 1 | 5 | 0 | 3 | 5 | 1.67 | 5.0 |
| 27 | Malik Knowles | Kansas St | JR | WR | 1 | 4 | 0 | 1 | 4 | 4.00 | 4.0 |
| 28 | Jeremiah Hall | Oklahoma | SR | TE | 1 | 3 | 0 | 1 | 3 | 3.00 | 3.0 |
| 29 | Dillon Doyle | Baylor | JR | LB | 2 | 5 | 0 | 2 | 5 | 2.50 | 2.5 |
| 29 | Dominic Richardson | Okla St | SO | RB | 2 | 5 | 0 | 8 | 5 | 0.63 | 2.5 |
| 31 | Drew Estrada | Baylor | SR | WR | 2 | 1 | 0 | 1 | 1 | 1.00 | 0.5 |
| 32 | John Paul Richardson | Okla St | FR | WR | 2 | -1 | 0 | 1 | -1 | -1.00 | -0.5 |
| 33 | Tyquan Thornton | Baylor | SR | WR | 2 | -11 | 0 | 1 | -11 | -11.00 | -5.5 |
Note: To qualify, player must have played in 75% of his team's games.