2021 Big 12 Conference Leaders Total Offense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Donovan Smith | Texas Tech | FR | QB | 6 | 105 | 783 | 106 | 888 | 8.38 | 148.0 |
| 2 | Max Duggan | TCU | JR | QB | 4 | 108 | 739 | 116 | 847 | 7.30 | 211.8 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 6 | 238 | 1044 | 178 | 1282 | 7.20 | 213.7 |
| 4 | Brock Purdy | Iowa State | SR | QB | 7 | 116 | 1785 | 278 | 1901 | 6.84 | 271.6 |
| 5 | Deuce Vaughn | Kansas St | SO | RB | 6 | 649 | 0 | 97 | 649 | 6.69 | 108.2 |
| 6 | Casey Thompson | Texas | JR | QB | 6 | 86 | 898 | 150 | 984 | 6.56 | 164.0 |
| 7 | Jason Bean | Kansas | JR | QB | 5 | 198 | 642 | 129 | 840 | 6.51 | 168.0 |
| 8 | Kennedy Brooks | Oklahoma | JR | RB | 6 | 723 | 0 | 114 | 723 | 6.34 | 120.5 |
| 9 | Gerry Bohanon | Baylor | JR | QB | 6 | 110 | 920 | 164 | 1030 | 6.28 | 171.7 |
| 10 | Abram Smith | Baylor | SR | RB | 7 | 743 | 0 | 126 | 743 | 5.90 | 106.1 |
| 11 | Spencer Sanders | Okla St | JR | QB | 7 | 309 | 1526 | 317 | 1835 | 5.79 | 262.1 |
| 12 | Emari Demercado | TCU | SR | RB | 5 | 266 | 0 | 48 | 266 | 5.54 | 53.2 |
| 13 | Breece Hall | Iowa State | JR | RB | 6 | 763 | 0 | 139 | 763 | 5.49 | 127.2 |
| 14 | Jarret Doege | WVU | SR | QB | 7 | -80 | 1509 | 263 | 1429 | 5.43 | 204.1 |
| 15 | Jaylen Warren | Okla St | SR | RB | 7 | 684 | 0 | 130 | 684 | 5.26 | 97.7 |
| 16 | Bijan Robinson | Texas | SO | RB | 5 | 555 | 0 | 109 | 555 | 5.09 | 111.0 |
| 17 | Devin Neal | Kansas | FR | RB | 6 | 457 | 0 | 90 | 457 | 5.08 | 76.2 |
| 18 | Leddie Brown | WVU | SR | RB | 6 | 525 | 0 | 107 | 525 | 4.91 | 87.5 |
| 19 | SaRodorick Thompson | Texas Tech | JR | RB | 6 | 295 | 0 | 61 | 295 | 4.84 | 49.2 |
| 20 | Trestan Ebner | Baylor | SR | RB | 7 | 350 | 0 | 74 | 350 | 4.73 | 50.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.