2021 Big 12 Conference Leaders Passes Defended - Games vs. FCS (I-AA) Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | DaMarcus Fields | Texas Tech | SR | DB | 1 | 0 | 2 | 2 | 2.00 |
| 1 | Colin Schooler | Texas Tech | SR | LB | 1 | 0 | 2 | 2 | 2.00 |
| 3 | Datrone Young | Iowa State | SR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Isheem Young | Iowa State | SO | DB | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Jaylen Pickle | Kansas St | JR | DT | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Bryson Washington | Oklahoma | FR | S | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 1 | 1 | 0 | 1 | 1.00 |
| 3 | Cole Maxwell | Baylor | SR | DT | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Kalon Barnes | Baylor | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | AJ McCarty | Baylor | FR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Matt Jones | Baylor | SO | LB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Anthony Johnson Jr. | Iowa State | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Eyioma Uwazurike | Iowa State | SR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Russ Yeast | Kansas St | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Julius Brents | Kansas St | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Ross Elder | Kansas St | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | TJ Smith | Kansas St | FR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Malcolm Lee | Kansas | SR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 3 | O.J. Burroughs | Kansas | FR | S | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Kenny Logan Jr. | Kansas | JR | S | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Jeremy Webb | Kansas | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Malcolm Rodriguez | Okla St | SR | LB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Christian Holmes | Okla St | SR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Kolby Harvell-Peel | Okla St | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 3 | C.J. Ceasar II | TCU | JR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Colt Ellison | TCU | JR | DE | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Eric Monroe | Texas Tech | SR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Rayshad Williams | Texas Tech | JR | DB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Tony Bradford Jr. | Texas Tech | JR | DL | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Alonzo Addae | WVU | SR | S | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Charles Woods | WVU | JR | CB | 1 | 0 | 1 | 1 | 1.00 |
| 3 | Andrew Wilson-Lamp | WVU | FR | CB | 1 | 0 | 1 | 1 | 1.00 |