2021 Big 12 Conference Leaders Interceptions - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Wyatt Harris | TCU | JR | LB | 1 | 1 | 47 | 0 | 1.00 |
| 1 | Tee Denson | Kansas St | SO | DB | 1 | 1 | 26 | 0 | 1.00 |
| 1 | Isheem Young | Iowa State | SO | DB | 1 | 1 | 5 | 0 | 1.00 |
| 1 | Dee Winters | TCU | JR | LB | 1 | 1 | 5 | 0 | 1.00 |
| 1 | Deshawn McCuin | TCU | SO | S | 1 | 1 | 0 | 0 | 1.00 |
| 1 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 72 | 1 | 0.50 |
| 1 | JT Woods | Baylor | SR | S | 2 | 1 | 20 | 1 | 0.50 |
| 1 | Jalen Pitre | Baylor | SR | S | 2 | 1 | 20 | 0 | 0.50 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 2 | 1 | 13 | 1 | 0.50 |
| 1 | Jairon McVea | Baylor | SR | S | 2 | 1 | 0 | 0 | 0.50 |
| 1 | Eric Monroe | Texas Tech | SR | DB | 2 | 1 | 0 | 0 | 0.50 |
| 1 | Adrian Frye | Texas Tech | SR | DB | 2 | 1 | 0 | 0 | 0.50 |
| 1 | Reggie Pearson Jr. | Texas Tech | JR | DB | 2 | 1 | 0 | 0 | 0.50 |
| 1 | Malcolm Rodriguez | Okla St | SR | LB | 3 | 1 | 11 | 0 | 0.33 |
| 1 | Kolby Harvell-Peel | Okla St | SR | S | 3 | 1 | 0 | 0 | 0.33 |