2021 Big 12 Conference Leaders Passing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 67 | 36 | 53.7 | 630 | 9.4 | 6 | 4 | 150.33 | 22.3 | 210.0 |
| 2 | Kansas | 3 | 72 | 49 | 68.1 | 671 | 9.3 | 3 | 1 | 157.31 | 24.0 | 223.7 |
| 3 | West Virginia | 4 | 101 | 64 | 63.4 | 724 | 7.2 | 5 | 1 | 137.94 | 25.3 | 181.0 |
| 4 | Iowa State | 4 | 107 | 63 | 58.9 | 617 | 5.8 | 2 | 4 | 106.00 | 26.8 | 154.3 |
| 5 | Kansas State | 4 | 110 | 74 | 67.3 | 814 | 7.4 | 5 | 6 | 133.52 | 27.5 | 203.5 |
| 6 | Texas | 3 | 83 | 61 | 73.5 | 548 | 6.6 | 1 | 1 | 130.52 | 27.7 | 182.7 |
| 7 | Baylor | 4 | 127 | 71 | 55.9 | 802 | 6.3 | 3 | 6 | 107.30 | 31.8 | 200.5 |
| 8 | Oklahoma | 4 | 146 | 94 | 64.4 | 1014 | 6.9 | 7 | 3 | 134.43 | 36.5 | 253.5 |
| 9 | Oklahoma State | 4 | 176 | 103 | 58.5 | 1209 | 6.9 | 7 | 2 | 127.07 | 44.0 | 302.3 |
| 10 | Texas Tech | 4 | 178 | 110 | 61.8 | 998 | 5.6 | 6 | 6 | 113.28 | 44.5 | 249.5 |