2021 Big 12 Conference Leaders Passing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma | 2 | 51 | 31 | 60.8 | 331 | 6.5 | 2 | 3 | 116.48 | 25.5 | 165.5 |
| 2 | Oklahoma State | 2 | 61 | 50 | 82.0 | 487 | 8.0 | 5 | 0 | 176.09 | 30.5 | 243.5 |
| 3 | Baylor | 2 | 65 | 43 | 66.2 | 650 | 10.0 | 3 | 3 | 156.15 | 32.5 | 325.0 |
| 4 | Kansas State | 5 | 146 | 110 | 75.3 | 1198 | 8.2 | 7 | 2 | 157.34 | 29.2 | 239.6 |
| 5 | Iowa State | 6 | 172 | 110 | 64.0 | 1234 | 7.2 | 10 | 5 | 137.59 | 28.7 | 205.7 |
| 6 | West Virginia | 7 | 201 | 138 | 68.7 | 1637 | 8.1 | 11 | 4 | 151.15 | 28.7 | 233.9 |
| 7 | Texas | 7 | 237 | 152 | 64.1 | 1639 | 6.9 | 11 | 5 | 133.33 | 33.9 | 234.1 |
| 8 | Texas Tech | 6 | 171 | 117 | 68.4 | 1675 | 9.8 | 17 | 1 | 182.34 | 28.5 | 279.2 |
| 9 | TCU | 7 | 178 | 120 | 67.4 | 1679 | 9.4 | 13 | 5 | 165.14 | 25.4 | 239.9 |
| 10 | Kansas | 10 | 243 | 178 | 73.3 | 2329 | 9.6 | 20 | 5 | 176.80 | 24.3 | 232.9 |