2021 Big 12 Conference Leaders Opponent First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 5 | 36 | 35 | 6 | 77 | 15.4 |
| 2 | Oklahoma State | 4 | 19 | 47 | 6 | 72 | 18.0 |
| 3 | West Virginia | 3 | 17 | 35 | 4 | 56 | 18.7 |
| 4 | Baylor | 5 | 41 | 51 | 10 | 102 | 20.4 |
| 5 | Kansas State | 3 | 29 | 35 | 5 | 69 | 23.0 |
| 6 | Texas Tech | 4 | 31 | 55 | 7 | 93 | 23.3 |
| 7 | Texas | 5 | 57 | 54 | 6 | 117 | 23.4 |
| 8 | Oklahoma | 3 | 34 | 30 | 7 | 71 | 23.7 |
| 9 | TCU | 3 | 37 | 30 | 10 | 77 | 25.7 |
| 10 | Kansas | 3 | 42 | 33 | 3 | 78 | 26.0 |