2021 Big 12 Conference Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 326 | 827 | 2.54 | 7 | 32.60 | 82.70 |
| 2 | Oklahoma | 10 | 326 | 1049 | 3.22 | 9 | 32.60 | 104.90 |
| 3 | Iowa State | 8 | 271 | 961 | 3.55 | 6 | 33.88 | 120.13 |
| 4 | Baylor | 9 | 291 | 1080 | 3.71 | 9 | 32.33 | 120.00 |
| 4 | Kansas State | 10 | 335 | 1244 | 3.71 | 10 | 33.50 | 124.40 |
| 6 | West Virginia | 10 | 361 | 1473 | 4.08 | 12 | 36.10 | 147.30 |
| 7 | Texas Tech | 9 | 292 | 1269 | 4.35 | 15 | 32.44 | 141.00 |
| 8 | Texas | 7 | 261 | 1220 | 4.67 | 13 | 37.29 | 174.29 |
| 9 | TCU | 9 | 327 | 1808 | 5.53 | 22 | 36.33 | 200.89 |
| 10 | Kansas | 9 | 369 | 2186 | 5.92 | 30 | 41.00 | 242.89 |