2021 Big 12 Conference Leaders Passing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 67 | 36 | 53.7 | 630 | 9.4 | 6 | 4 | 150.33 | 22.3 | 210.0 |
| 2 | Iowa State | 4 | 93 | 56 | 60.2 | 583 | 6.3 | 4 | 3 | 120.62 | 23.3 | 145.8 |
| 3 | Baylor | 4 | 113 | 62 | 54.9 | 596 | 5.3 | 3 | 4 | 100.85 | 28.3 | 149.0 |
| 4 | Kansas | 4 | 96 | 68 | 70.8 | 940 | 9.8 | 5 | 1 | 168.19 | 24.0 | 235.0 |
| 5 | Oklahoma State | 4 | 139 | 79 | 56.8 | 898 | 6.5 | 3 | 2 | 115.34 | 34.8 | 224.5 |
| 6 | West Virginia | 4 | 124 | 82 | 66.1 | 871 | 7.0 | 6 | 1 | 139.49 | 31.0 | 217.8 |
| 7 | Texas | 4 | 118 | 88 | 74.6 | 940 | 8.0 | 4 | 3 | 147.60 | 29.5 | 235.0 |
| 8 | Kansas State | 4 | 133 | 89 | 66.9 | 1020 | 7.7 | 4 | 4 | 135.25 | 33.3 | 255.0 |
| 9 | Oklahoma | 4 | 140 | 90 | 64.3 | 887 | 6.3 | 4 | 3 | 122.65 | 35.0 | 221.8 |
| 10 | Texas Tech | 4 | 148 | 96 | 64.9 | 1011 | 6.8 | 10 | 6 | 136.44 | 37.0 | 252.8 |