2021 Big 12 Conference Leaders Opponent Penalties - Games in August/September Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Iowa State | 4 | 25 | 225 | 6.3 | 56.3 |
| 2 | Kansas State | 4 | 27 | 216 | 6.8 | 54.0 |
| 3 | Oklahoma | 4 | 25 | 191 | 6.3 | 47.8 |
| 3 | Texas Tech | 4 | 25 | 191 | 6.3 | 47.8 |
| 5 | Kansas | 4 | 23 | 190 | 5.8 | 47.5 |
| 6 | Oklahoma State | 4 | 20 | 179 | 5.0 | 44.8 |
| 7 | Texas | 4 | 22 | 164 | 5.5 | 41.0 |
| 8 | TCU | 3 | 17 | 145 | 5.7 | 48.3 |
| 9 | West Virginia | 4 | 18 | 144 | 4.5 | 36.0 |
| 10 | Baylor | 4 | 12 | 103 | 3.0 | 25.8 |