2021 Big 12 Conference Leaders Passing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 19 | 10 | 52.6 | 94 | 4.9 | 0 | 1 | 83.65 | 19.0 | 94.0 |
| 2 | Texas Tech | 2 | 67 | 40 | 59.7 | 365 | 5.4 | 4 | 5 | 110.23 | 33.5 | 182.5 |
| 3 | Texas | 2 | 64 | 47 | 73.4 | 410 | 6.4 | 1 | 0 | 132.41 | 32.0 | 205.0 |
| 4 | TCU | 1 | 28 | 17 | 60.7 | 245 | 8.8 | 4 | 3 | 159.92 | 28.0 | 245.0 |
| 4 | Kansas | 1 | 21 | 17 | 81.0 | 245 | 11.7 | 2 | 0 | 210.38 | 21.0 | 245.0 |
| 6 | Baylor | 2 | 71 | 42 | 59.2 | 498 | 7.0 | 2 | 3 | 118.93 | 35.5 | 249.0 |
| 7 | Oklahoma | 1 | 45 | 27 | 60.0 | 296 | 6.6 | 3 | 0 | 137.26 | 45.0 | 296.0 |
| 8 | Kansas State | 1 | 41 | 28 | 68.3 | 306 | 7.5 | 1 | 1 | 134.15 | 41.0 | 306.0 |
| 9 | Oklahoma State | 3 | 130 | 79 | 60.8 | 975 | 7.5 | 6 | 2 | 135.92 | 43.3 | 325.0 |