2021 Big 12 Conference Leaders Passes Defended - Games at Home Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | TCU | 7 | 8 | 12 | 20 | 2.86 |
| 2 | Oklahoma | 7 | 7 | 12 | 19 | 2.71 |
| 3 | Baylor | 7 | 5 | 20 | 25 | 3.57 |
| 3 | Kansas State | 7 | 5 | 19 | 24 | 3.43 |
| 5 | Oklahoma State | 7 | 4 | 25 | 29 | 4.14 |
| 5 | Iowa State | 6 | 4 | 12 | 16 | 2.67 |
| 7 | Texas Tech | 6 | 3 | 27 | 30 | 5.00 |
| 7 | Kansas | 6 | 3 | 15 | 18 | 3.00 |
| 7 | Texas | 6 | 3 | 11 | 14 | 2.33 |
| 7 | West Virginia | 6 | 3 | 11 | 14 | 2.33 |